The problem gets worse in pipelines. When you chain multiple transforms — say, parse, transform, then serialize — each TransformStream has its own internal readable and writable buffers. If implementers follow the spec strictly, data cascades through these buffers in a push-oriented fashion: the source pushes to transform A, which pushes to transform B, which pushes to transform C, each accumulating data in intermediate buffers before the final consumer has even started pulling. With three transforms, you can have six internal buffers filling up simultaneously.
BioMarin也迅速跟进迭代研发，其升级版在研产品BMN333同样旨在实现周剂注射。早期临床结果显示BMN333的AUC水平高于其他长效CNP研究的3倍以上，公司研发主管Greg Friberg表示该药对标的正是TransCon-CNP。
。业内人士推荐同城约会作为进阶阅读
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До этого операторы 6-й дивизии ликвидировали в Константиновке две цели. Сначала бойцы ликвидировали брошенный американский бронетранспортер (БТР) М-113, а затем — британский FV-103 Spartan.